Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma

Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Konjevod, Marcela; Tudor, Lucija; Nikolac Perković, Matea; Jukic, Irena; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Markeljevic, Jasenka; Pivac, Nela; Švob Štrac, Dubravka (2020) Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine, 10 (4). ISSN 2075-4426

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Abstract

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses ; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects ; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity.

Item Type:	Article
Uncontrolled Keywords:	asthma ; plasma BDNF concentration ; BDNF and NTRK2 (TrkB gene) polymorphisms ; severity ; phenotypes ; aspirin
Subjects:	INTERDISCIPLINARY AREAS OF KNOWLEDGE > Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Divisions:	Division of Molecular Medicine
Depositing User:	Dubravka Švob Štrac
Date Deposited:	10 Nov 2020 12:59
URI:	http://fulir.irb.hr/id/eprint/5993
DOI:	10.3390/jpm10040189

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