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The Role of Vitamin D in Inflammatory Bowel Disease – Assessing Therapeutic and Preventive Potential of Supplementation and Food Fortification

Leskovar, Dunja; Meštrović, Tomislav; Barešić, Anja; Kraljević, Ivana; Panek, Marina; Čipčić Paljetak, Hana; Perić, Mihaela; Matijašić, Mario; Rogić, Dunja; Barišić, Ana; Ljubas Kelečić, Dina; Vranešić Bender, Darija; Krznarić, Željko; Verbanac, Donatella (2018) The Role of Vitamin D in Inflammatory Bowel Disease – Assessing Therapeutic and Preventive Potential of Supplementation and Food Fortification. Food Technology and Biotechnology, 56 (4). pp. 456-463. ISSN 1330-9862

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Inflammatory bowel diseases are a group of chronic inflammatory conditions that affect gastrointestinal tract due to inapt and continuous immune activation in response to a myriad of predisposing factors (most notably genetics, environmental impact and gut microbiota composition). It has been shown that vitamin D status can also play a role in the disease pathogenesis, as its deficiency is commonly observed in two major forms of inflammatory bowel diseases – Crohn’s disease and ulcerative colitis. Mounting evidence supports the concept of intricate relationship between gut dysbiosis and vitamin D metabolism, while suboptimal levels of this vitamin have been linked to increased clinical disease relapse rates, inadequate response to drugs, as well as decreased quality of life in patients with Crohn’s disease and ulcerative colitis. Consequently, the pertinent question is whether increased vitamin D supplementation and (on a population level) food fortification may bring significant benefit to the affected individuals. In this short review we discuss the synthesis, functions, status and food sources of vitamin D, appraise biotechnological facets of vitamin D status analysis and food fortification, and concentrate on novel developments in the field that describe its influence on intestinal microbiota and inflammatory bowel disease.

Item Type: Article
Additional Information: The authors fully acknowledge the Croatian Science Foundation (Hrvatska Zaklada za Znanost, HRZZ) for the support of this work under the project MINUTE for IBD (HRZZ grant no IP-11-2013-5467).
Uncontrolled Keywords: inflammatory bowel diseases; Crohn’s disease; ulcerative colitis; vitamin D; gut
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Internal Medicine
BIOTECHNICAL SCIENCES > Food Technology > Nutrition
Project titleProject leaderProject codeProject type
Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijeva-MINUTE for IBDDonatella VerbanacIP-2013-11-5467HRZZ
Depositing User: Anja Barešić
Date Deposited: 28 Jul 2020 11:30
DOI: 10.17113/ftb.

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