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N-glycomic Profile in Combat Related Post- Traumatic Stress Disorder

Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Konjevod, Marcela; Švob Štrac, Dubravka; Uzun, Suzana; Kozumplik, Oliver; Jovanovic, Tanja; Lauc, Gordan; Pivac, Nela (2019) N-glycomic Profile in Combat Related Post- Traumatic Stress Disorder. Biomolecules, 9 (12). ISSN 2218-273X

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Post-traumatic stress disorder (PTSD) develops in a portion of individuals exposed to extreme trauma. Glycosylation is a post-translational modification that affects protein functions and is altered in various pathophysiological states and aging. There are still no validated biomarkers of PTSD. The aim of this study was to evaluate the N-glycomic profile in 543 male Caucasian individuals (299 veterans with PTSD and 244 control subjects). The study included discovery (N = 233) and replication (N = 310) cohort. Hydrophilic interaction HPLC and ultra- performance liquid chromatography were used to separate and detect 39 plasma and 24 IgG N- glycan species, respectively. All results were corrected for the effects of age and multiple testing. Significant results included only significantly altered N-glycans in cases/controls in both cohorts, in the same direction. Results showed that six plasma N- glycans (four increased and two decreased) were altered in PTSD vs. controls in both cohorts, but IgG N-glycans were similar between groups. The severity of PTSD was not associated with different plasma N-glycans. This is the first study detecting alterations in plasma N-glycans in PTSD. These N-glycans are also associated with other neuropsychiatric disorders and inflammation, suggesting possible shared glycosylation mechanisms.

Item Type: Article
Uncontrolled Keywords: Caucasians ; N-glycans ; PTSD ; biomarkers ; immunoglobulin G ; male subjects ; plasma ; veterans
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Genomski i glikanski biomarkeri PTSP-a-GlycoGenePTSDNela PivacIP-2014-09-4289HRZZ
Depositing User: Dubravka Švob Štrac
Date Deposited: 27 Dec 2019 11:21
DOI: 10.3390/biom9120834

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