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Multicomponent Approach to a Library of N- Substituted γ-Lactams

Suć Sajko, Josip; Ljoljić Bilić, Vanja; Kosalec, Ivan; Jerić, Ivanka (2019) Multicomponent Approach to a Library of N- Substituted γ-Lactams. ACS Combinatorial Science, 21 (1). pp. 28-34. ISSN 2156-8952

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The γ-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted γ-lactams following a single-pot, three-component Ugi reaction comprising bifunctional building block, l-glutamic acid methyl ester. The reaction tolerates structurally diverse carbonyl and isocyanide components providing a robust access to functionalized γ-lactams. Antimicrobial susceptibility testing, including agar well diffusion assay, serial microdilution broth assay, and antibiofilm activity testing, identified a potent compound with antibiofilm activity against Staphylococcus aureus ATCC 6538.

Item Type: Article
Uncontrolled Keywords: antibiofilm activity ; multicomponent reactions ; Ugi reaction ; γ-lactams
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Project titleProject leaderProject codeProject type
Višekomponentne reakcije u sintezi peptidnih mimetika-MIMICRyIVANKA JERIĆIP-2014-09-3102HRZZ
Depositing User: Ivanka Jerić
Date Deposited: 19 Nov 2019 12:26
DOI: 10.1021/acscombsci.8b00147

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