Multicomponent Approach to a Library of N- Substituted γ-Lactams

Suć Sajko, Josip; Ljoljić Bilić, Vanja; Kosalec, Ivan; Jerić, Ivanka (2019) Multicomponent Approach to a Library of N- Substituted γ-Lactams. ACS Combinatorial Science, 21 (1). pp. 28-34. ISSN 2156-8952

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Abstract

The γ-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted γ-lactams following a single-pot, three-component Ugi reaction comprising bifunctional building block, l-glutamic acid methyl ester. The reaction tolerates structurally diverse carbonyl and isocyanide components providing a robust access to functionalized γ-lactams. Antimicrobial susceptibility testing, including agar well diffusion assay, serial microdilution broth assay, and antibiofilm activity testing, identified a potent compound with antibiofilm activity against Staphylococcus aureus ATCC 6538.

Item Type:	Article
Uncontrolled Keywords:	antibiofilm activity ; multicomponent reactions ; Ugi reaction ; γ-lactams
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Višekomponentne reakcije u sintezi peptidnih mimetika-MIMICRy IVANKA JERIĆ IP-2014-09-3102 HRZZ
Depositing User:	Ivanka Jerić
Date Deposited:	19 Nov 2019 12:26
URI:	http://fulir.irb.hr/id/eprint/5068
DOI:	10.1021/acscombsci.8b00147

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