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Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula

Perina, Dragutin; Korolija, Marina; Popović Hadžija, Marijana; Grbeša, Ivana; Belužić, Robert; Imešek, Mirna; Morrow, Christine; Posavec Marjanović, Melanija; Bakran- Petricioli, Tatjana; Mikoč, Andreja; Ćetković, Helena (2015) Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula. In: Marine Compounds and Cancer. Marine Drugs . MDPI Books, Basel, Switzerland, pp. 700-717. ISBN 978-3-03842-131-3

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Finkel-Biskis-Reilly murine sarcoma virus (FBR- MuSV) ubiquitously expressed (FAU) gene is down-regulated in human prostate, breast and ovarian cancers. Moreover, its dysregulation is associated with poor prognosis in breast cancer. Sponges (Porifera) are animals without tissues which branched off first from the common ancestor of all metazoans. A large majority of genes implicated in human cancers have their homologues in the sponge genome. Our study suggests that FAU gene from the sponge Suberites domuncula reflects characteristics of the FAU gene from the metazoan ancestor, which have changed only slightly during the course of animal evolution. We found pro-apoptotic activity of sponge FAU protein. The same as its human homologue, sponge FAU increases apoptosis in human HEK293T cells. This indicates that the biological functions of FAU, usually associated with “higher” metazoans, particularly in cancer etiology, possess a biochemical background established early in metazoan evolution. The ancestor of all animals possibly possessed FAU protein with the structure and function similar to evolutionarily more recent versions of the protein, even before the appearance of true tissues and the origin of tumors and metastasis. It provides an opportunity to use pre-bilaterian animals as a simpler model for studying complex interactions in human cancerogenesis.

Item Type: Book Section
Uncontrolled Keywords: ribosomal protein genes ; snoRNA ; FAU ; RPS30 ; SNORA62 ; evolution ; Porifera
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Molecular Biology
Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Geni i genomi: struktura, funkcija i evolucija-Helena Ćetković098-0982913-2874MZOS
Depositing User: Marijana Popović Hadžija
Date Deposited: 24 Jul 2019 14:36

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