hrvatski jezikClear Cookie - decide language by browser settings

Efficiency of Dinucleosides as the Backbone to Pre-Organize Multi-Porphyrins and Enhance Their Stability as Sandwich Type Complexes with DABCO

Merkaš, Sonja; Bouatra, Souhaila; Rein, Régis; Piantanida, Ivo; Žinić, Mladen; Solladié, Nathalie (2017) Efficiency of Dinucleosides as the Backbone to Pre-Organize Multi-Porphyrins and Enhance Their Stability as Sandwich Type Complexes with DABCO. Molecules, 22 (7). ISSN 1420-3049

[img]
Preview
PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (2MB) | Preview

Abstract

Flexible linkers such as uridine or 2′-deoxyuridine pre-organize bis-porphyrins in a face-to-face conformation, thus forming stable sandwich complexes with a bidentate base such as 1, 4-diazabicyclo[2.2.2]octane (DABCO). Increased stability can be even greater when a dinucleotide linker is used. Such pre-organization increases the association constant by one to two orders of magnitude when compared to the association constant of DABCO with a reference porphyrin. Comparison with rigid tweezers shows a better efficiency of nucleosidic dimers. Thus, the choice of rigid spacers is not the only way to pre-organize bis-porphyrins, and well-chosen nucleosidic linkers offer an interesting option for the synthesis of such devices.

Item Type: Article
Uncontrolled Keywords: porphyrins ; nucleosides ; supramolecular complexes
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala-Leo Frkanec098-0982904-2912MZOS
Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima-Ivo Piantanida098-0982914-2918MZOS
Depositing User: Ivo Piantanida
Date Deposited: 12 Jun 2019 12:55
Last Modified: 12 Jun 2019 12:55
URI: http://fulir.irb.hr/id/eprint/4550
DOI: 10.3390/molecules22071112

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year