Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

Novak Kujundžić, Renata; Stepanić, Višnja; Milković, Lidija; Čipak Gašparović, Ana; Tomljanović, Marko; Gall-Troselj, Koraljka (2019) Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer. International journal of molecular sciences, 20 (5). ISSN 1422-0067

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Official URL: https://www.mdpi.com/1422-0067/20/5/1180

Abstract

Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti- inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century.

Item Type:

Article

Uncontrolled Keywords:

curcumin ; oxidative metabolites ; inflamm-aging ; cancer ; metabolic reprogramming ; direct protein binding ; IL-17 ; STAT3 ; SHMT2

Subjects:

NATURAL SCIENCES > Interdisciplinary Natural Sciences
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences

Divisions:

Division of Molecular Medicine

Projects: