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Dynein, microtubule and cargo: a ménage à trois

Pavin, Nenad; Tolić‑Nørrelykke, Iva M. (2013) Dynein, microtubule and cargo: a ménage à trois. Biochemical Society Transactions, 41 (6). pp. 1731-1735. ISSN 0300-5127

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To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell.

Item Type: Article
Uncontrolled Keywords: cargo ; cortical anchor ; dynein ; microtubule ; motor protein ; targeting
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Molecular Biology
Depositing User: Iva Tolić
Date Deposited: 05 Mar 2019 13:46
DOI: 10.1042/BST20130235

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