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ESI-MS studies of the non-covalent interactions between biologically important metal ions and N-sulfonylcytosine derivatives

Ključarić, Valentina; Kobetić, Renata; Rinkovec, Jasmina; Kazazić, Snježana; Gembarovski, Dubravka; Saftić, Dijana; Matić, Josipa; Ban, Željka; Žinić, Biserka (2016) ESI-MS studies of the non-covalent interactions between biologically important metal ions and N-sulfonylcytosine derivatives. Journal of Mass Spectrometry, 51 . pp. 998-1005. ISSN 1076-5174

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Abstract

The aim of this report is to present the electrospray ionization mass spectrometry results of the non-covalent interaction of two biologically active ligands, N-1-(p-toluenesulfonyl)cytosine, 1-TsC, 1 and N-1 methanesulfonylcytosine, 1-MsC, 2 and their Cu(II) complexes Cu(1-TsCN3)2Cl2, 3 and Cu(1-MsC-N3)2Cl2 and 4 with biologically important cations: Na+, K+, Ca2+, Mg2+ and Zn2+. The formation of various complex metal ions was observed. The alkali metals Na+ and K+ formed clusters because of electrostatic interactions. Ca2+ andMg2+ salts produced the tris ligand andmixed ligand complexes. The interaction of Zn2+ with 1–4 produced monometal and dimetal Zn2+ complexes as a result of the affinity of Zn2+ ions toward both O and N atoms.

Item Type: Article
Additional Information: This work was supported by the Croatian Ministry of Science, Education and Sport through grant nos. 098-0982914-2935 and 098-0982904-2912 and the Rudjer Boskovic Institute's spin-off company BioZyne d.o.o. Financial support from the Croatian Science Foundation (grant no. HRZZ-1477) is gratefully acknowledged.) The authors would like to acknowledge the contribution of COST action TD 1304, the Network for the Biology of Zinc (Zinc-Net).
Uncontrolled Keywords: N-1-sulfonylcytosine derivatives; Cu(II) complexes; metal ions Na+, K+, Ca2+, Mg2+ and Zn2+; non-covalent interactions; ESI-MS
Subjects: NATURAL SCIENCES
NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Chemistry > Analytic Chemistry
NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Division of Physical Chemistry
Projects:
Project titleProject leaderProject codeProject type
Sinteza novih biološki aktivnih derivata nukleobaza i nukleotida-Biserka Žinić098-0982914-2935MZOS
Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala-Leo Frkanec098-0982904-2912MZOS
Rudjer Boskovic Institute's spin-off company BioZyne d.o.o.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima-DNA/RNA-MolSenseIvo PiantanidaIP-2013-11-1477HRZZ
COST actionUNSPECIFIEDTD1304UNSPECIFIED
Depositing User: Dijana Saftić
Date Deposited: 02 May 2018 13:14
Last Modified: 02 May 2018 13:14
URI: http://fulir.irb.hr/id/eprint/4022
DOI: 10.1002/jms.3810

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