Genetic and phytochemical variability of six Teucrium arduini L. populations and their antioxidant/prooxidant behavior examined by biochemical, macromolecule- and cell-based approaches

Šamec, Dunja; Durgo, Ksenija; Gruz, Jiri; Kremer, Dario; Kosalec, Ivan; Piljac Žegarac, Jasenka; Salopek Sondi, Branka (2015) Genetic and phytochemical variability of six Teucrium arduini L. populations and their antioxidant/prooxidant behavior examined by biochemical, macromolecule- and cell-based approaches. Food Chemistry, 186 . pp. 298-305. ISSN 0308-8146

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Abstract

Teucrium arduini L., an Ilyric-Balcanic endemic species, has been reported for decades as a valuable plant used in traditional medicine for treating digestive disorders. The present study evaluated genetic and phytochemical variability of six T. arduini populations in order to determine factors that influence an accumulation of polyphenolic compounds. Results strongly suggest that a phytochemical variation was caused by environmental rather than genetic factors. T. arduini leaf extract from the locality Učka which accumulated significantly more polyphenolic phytochemicals in comparison to others showed antioxidant activity in DNA and lipid bioassays. Furthermore, the same extract exhibited prooxidant behavior at protein level and induce formation of reactive oxygen species in human laryngeal carcinoma cells causing cytotoxic activity, in a dose dependent manner. All the results of the present study suggested that T. arduini extract could be responsible for antioxidative/prooxidative mechanisms and would help in determination of optimal conditions for their ethnopharmacological use.

Item Type:	Article
Uncontrolled Keywords:	antioxidative/prooxidative activity; cytotoxicity; ethnopharmacology; macromolecule bioassay; polyphenols; Teucrium arduini L.
Subjects:	NATURAL SCIENCES > Biology NATURAL SCIENCES > Biology > Botany
Divisions:	Division of Molecular Biology
Projects:	Project title Project leader Project code Project type Molekularna regulacija biljnog razvitka- Branka Salopek-Sondi 098-0982913-2829 MZOS Mikromorfološka i kemotaksonomska istraživanja nekih vrsta porodice Lamiaceae- Dario Kremer 006-0000000-3178 MZOS Utjecaj mutagena i antimutagena na molekularne procese u stanici- Reno Hrašćan 058-0582261-2246 MZOS INHIBICIJA KOROZIJE PRIRODNIM SPOJEVIMA: OD MOLEKULSKIH MODELA DO PRIMJENE- Sanja Martinez 125-0822161-2982 MZOS Operational Program Education for Competitiveness - European Social Fund UNSPECIFIED CZ.1.07/2.3.00/20.0165 UNSPECIFIED program "Navrat" for Research, Development, and Innovations" - Ministry of Education, Youth and Sports of the Czech Republic UNSPECIFIED LK21306 UNSPECIFIED
Depositing User:	Dunja Šamec
Date Deposited:	27 Nov 2017 16:03
URI:	http://fulir.irb.hr/id/eprint/3684
DOI:	10.1016/j.foodchem.2014.07.135

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