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Reactive aldehydes – second messengers of free radicals in diabetes mellitus

Jaganjac, Morana; Tirosh, O.; Cohen, G.; Sasson, S.; Žarković, Neven (2013) Reactive aldehydes – second messengers of free radicals in diabetes mellitus. Free Radical Research, 47 (S1). pp. 39-48. ISSN 1071-5762

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Abstract

Elevated levels of pro-oxidants and various markers of oxidative tissue damage were found in diabetic patients, indicating involvement of oxidative stress in the pathogenesis of diabetes mellitus (DM). On one side, physiological levels of reactive oxygen species (ROS) play an important role in redox signaling of various cells, while on the other, excessive ROS production can jeopardize the integrity and physiological functions of cellular macromolecules, in particular proteins, thus contributing to the pathogenesis of DM. Reactive aldehydes, especially 4-hydroxynonenal (HNE), are considered as second messengers of free radicals that act both as signaling molecules and as cytotoxic products of lipid peroxidation causing long-lasting biological consequences, in particular by covalent modification of macromolecules. Accordingly, the HNE and related reactive aldehydes may play important roles in the pathophysiology of DM, both in the development of the disease and in its progression and complications due to the following: (i) exposure of cells to supraphysiological levels of 4-hydroxyalkenals, (ii) persistent and sustained generation of 4-hydroxyalkenals that progressively affect vulnerable cells that lack an efficient bioactive aldehyde neutralization system, (iii) altered redox signaling influenced by reactive aldehydes, in particular by HNE, and (iv) induction of extracellular generation of similar aldehydes under secondary pathological conditions, such as low-grade inflammation.

Item Type: Article
Uncontrolled Keywords: 4-hydroxydodecadienal; 4-hydroxynonenal; advanced glycation end products; advanced lipoxidation end products; diabetes mellitus; lipid peroxidation; PPARδ; reactive aldehydes; reactive carbonyl compounds; reactive oxygen species
Subjects: NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji-Neven ZARKOVIC098-0982464-2519MZOS
Depositing User: Neven Žarković
Date Deposited: 25 Aug 2017 09:25
Last Modified: 25 Aug 2017 09:25
URI: http://fulir.irb.hr/id/eprint/3538
DOI: 10.3109/10715762.2013.789136

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