Female headstart in resistance to hyperoxia-induced oxidative stress

Šarić, Ana; Sobočanec, Sandra; Mačak-Šafranko, Željka; Popović Hadžija, Marijana; Aralica, Gorana; Korolija, Marina; Kušić, Borka; Balog, Tihomir (2014) Female headstart in resistance to hyperoxia-induced oxidative stress. Acta Biochimica Polonica, 61 (4). pp. 801-807. ISSN 0001-527X

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Abstract

Increased oxygen concentration (hyperoxia) induces oxidative damage of tissues and organs. Oxygen toxicity in hyperoxia is controlled by factors such as sex, age, tissue, strain and hormones. In most species females show lower incidence of some age-related pathologies linked with oxidative stress, which has been attributed to a beneficial effect of ovarian hormones. In this study we found that hyperoxia induced hepatic oxidative damage exclusively in male CBA/H mice, followed by their decreased survival. Histopathological examination revealed that the observed differences in survival were not the consequence of acute lung injury induced by hyperoxia. Next, we observed that an increased Sirt1 protein level in hyperoxia-exposed female CBA/H mice correlated with their lower PPAR-γ and higher eNOS and Sod2 protein levels. In males, higher PPAR-γ and lower Sod2 protein levels were associated with unchanged Sirt1 expression. Although these results are of a correlative nature only, they clearly show that females show better survival, increased resistance to hyperoxia and have generally more efficient defense systems, which suggests that their headstart in resistance to hyperoxia could be a consequence of the beneficial effect of ovarian hormones.

Item Type:	Article
Uncontrolled Keywords:	hyperoxia; oxidative stress; ageing; resistance
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Dobivanje struktura nalik Langerhansovim otočićima iz matičnih stanica miša- Mirko Hadžija 098-0982464-2460 MZOS Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu- Tihomir Balog 098-0982464-1647 MZOS
Depositing User:	Sandra Sobočanec
Date Deposited:	14 Jul 2016 12:11
URI:	http://fulir.irb.hr/id/eprint/2963

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