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A new look at cerebrospinal fluid movement

Orešković, Darko; Klarica, Marijan (2014) A new look at cerebrospinal fluid movement. Fluids and Barriers of the CNS, 11 . pp. 16-18. ISSN 2045-8118

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Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest that there are cardiac cycle-dependent systolic-diastolic to-and-fro cranio-spinal CSF movements. These are based on: a) physiological oscillations of arterial and venous blood during cranio-spinal blood circulation ; b) respiratory activity, and c) body activity and posture. That kind of complex CSF movement could explain the observed distribution of many different substances in all directions along the CSF system and within central nervous system tissue. It seems that efflux transport systems at capillary endothelium may be more important for brain homeostasis than the removal of metabolites by CSF flow. Thus, when discussing the CSF dynamics we suggest that a more appropriate term would be CSF movement rather than CSF circulation.

Item Type: Article
Uncontrolled Keywords: classic hypothesis of cerebrospinal physiology; cerebrospinal fluid circulation; cerebrospinal fluid movement; cerebrospinal fluid secretion; aquaporin Orešković and Klarica hypothesis
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Hydrodynamics of the cerebrospinal fluid (Hidrodinamika cerebrospinalnog fluida)Darko Orešković098-1080231-2328MZOS
Pathophysiology of the cerebrospinal fluid and intracranial pressure (Patofiziologija cerebrospinalnog likvora i intrakranijskog tlaka)Marijan Klarica108-1080231-0023MZOS
Depositing User: Darko Orešković
Date Deposited: 24 May 2016 13:02
DOI: 10.1186/2045-8118-11-16

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