Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer

Jaganjac, Morana; Čačev, Tamara; Čipak, Ana; Kapitanović, Sanja; Gall-Troselj, Koraljka; Žarković, Neven (2012) Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer. Croatian medical journal, 53 (4). pp. 304-309. ISSN 0353-9504

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Abstract

Pathophysiological processes associated with disturbances in cell and tissue oxidative homeostasis, are associated with self-catalyzed process of lipid peroxidation. The end products of lipid peroxidation are reactive aldehydes such as 4-hydroxy-2-nonenal (HNE), acting as "second messengers of free radicals." Although reactive aldehydes were first recognized only as cytotoxic, new evidence has come to light, related to their cell growth regulatory functions achieved through cell signaling. The variable appearance of HNE in several organs indicates that its mode of action might be related to an individual cell stress adaptation. The underlying mechanism could be that specific mutations and epigenetic changes on one hand interfere with hormesis on the other. The precise role of oxidative stress and lipid peroxidation in these processes still needs more clarification at molecular level. Finally, an individual approach to each patient, based on the individual cell response to stress, opens a new possibility of integrative medicine in cancer treatment and strongly supports modern concepts of personalized medicine.

Item Type:

Article

Uncontrolled Keywords:

oxidative stress, personalized medicine

Subjects:

BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences

Divisions:

Division of Molecular Medicine

Projects:

Project title	Project leader	Project code	Project type
Epigenetic and immunomodulatery changes in malignant head and neck tumors (Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata)-	Koraljka Gall-Trošelj	098-0982464-2511	MZOS
Molecular genetics and pharmacogenetics of gastrointestinal tumors (Molekularna genetika i farmakogenetika gastrointestinalnih tumora)-	Sanja Kapitanović	098-0982464-2508	MZOS
Lipids, free radicals and their messengers in integrative oncology (Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji)-	Neven Žarković	098-0982464-2519	MZOS