Human plasma glycome in attention‐deficit hyperactivity disorder and autism spectrum disorders

Pivac, Nela; Knežević, Ana; Gornik, Olga; Pučić, Maja; Igl, Wilmar; Peeters, Hilde; Crepel, An; Steyaert, Jean; Novokmet, Mislav; Redžić, Irma; Nikolac, Matea; Novković Hercigonja, Vesna; Dodig Ćurković, Katarina; Ćurković, Mario; Nedić, Gordana; Muck-Šeler, Dorotea; Borovečki, Fran; Rudan, Igor; Lauc, Gordan (2011) Human plasma glycome in attention‐deficit hyperactivity disorder and autism spectrum disorders. Molecular and cellular proteomics, 10 (1). pp. 1-7. ISSN 1535-9476

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Abstract

Over a half of all proteins are glycosylated, and their proper glycosylation is essential for normal function. Unfortunately, due to structural complexity of nonlinear branched glycans and the absence of genetic template for their synthesis, the knowledge about glycans is lagging significantly behind the knowledge about proteins or DNA. Using a recently developed quantitative high throughput glycan analysis methods we quantified components of the plasma N‐glycome in 99 children with attention‐deficit hyperactivity disorder (ADHD), 81 child and 5 adults with autism spectrum disorder (ASD) and total of 340 matching healthy controls. No changes in plasma glycome were found to associate with ASD, but several highly significant associations were observed with ADHD. Further structural analysis of plasma glycans revealed that ADHD is associated with increased antennary fucosylation of biantennary glycans and decreased levels of some complex glycans with three or four antennas. The design of this study prevented any functional conclusions about the observed associations, but specific differences in glycosylation appears to be strongly associated with ADHD what warrants further studies into this direction.

Item Type:	Article
Uncontrolled Keywords:	attention deficit hyperactivity disorder (ADHD); autism spectrum disorder (ASD); plasma
Subjects:	BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Determinants of health and disease in general and isolated human populations (Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama)- Ozren Polašek 216-1080315-0302 MZOS Genomic Analysis of Transcriptome and Interactome in Complex Disease Patients (Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima)- Fran Borovečki 108-1081874-1923 MZOS Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)- Dorotea Muck-Šeler 098-0982522-2457 MZOS Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)- Nela Pivac 098-0982522-2455 MZOS UNSPECIFIED UNSPECIFIED 309-0061194-2023 MZOS
Depositing User:	Matea Nikolac Perković
Date Deposited:	03 Dec 2015 15:04
URI:	http://fulir.irb.hr/id/eprint/2369
DOI:	10.1074/mcp.M110.004200

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