Association between the polymorphisms of the selected genes encoding dopaminergic system with ADHD and autism

Nikolac Perković, Matea; Nedić Erjavec, Gordana; Kocijan Hercigonja, Dubravka; Hranilović, Dubravka; Čurković, Mario; Štefulj, Jasminka; Dodig Čurković, Katarina; Muck-Šeler, Dorotea; Pivac, Nela (2013) Association between the polymorphisms of the selected genes encoding dopaminergic system with ADHD and autism. Psychiatry research, 215 (1). pp. 260-261. ISSN 0165-1781

Preview

PDF - Accepted Version
Download (139kB) | Preview

Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

Attention-deficit hyperactivity disorder (ADHD) and autism are both heritable, polygenic neurodevelopmental disorders with similar symptoms. Both disorders have onset in childhood and occur more frequently in boys than in girls. Genetic studies have so far focused mostly on candidate genes involved in dopaminergic system, however more non-replications than positive associations were reported. The present study tested the possible association of the variants in dopamine system genes with these disorders in Croatian population. Polymorphisms of the dopamine receptor D4 (DRD4 variable number of tandem repeats), catechol-o-methyltransferase (COMT Val108/158Met), dopamine-beta-hydroxylase (DBH -1021C/T) and monoamine oxidase type B (MAO-B intron 13 polymorphism) were analyzed in unrelated male Caucasian subjects: 128 control subjects, 102 children with ADHD and 80 subjects with autism, diagnosed according to DSM-IV criteria. This study detected significantly reduced frequency of DRD4 L allele in autistic compared to other groups and increased frequency of the COMT Met/Met genotype in autistic and ADHD groups compared to control group. The frequency of the genotypes of DBH -1021C/T and MAO-B intron 13 polymorphisms was similar between subjects with ADHD or autism and healthy subjects. These results suggest that DRD4 L allele and the COMT Met/Met genotype might be associated with ADHD and autism.

Item Type:

Article

Uncontrolled Keywords:

Attention-deficit hyperactivity disorder (ADHD); autism; dopamine receptor D4 (DRD4); catechol-o-methyltransferase (COMT); dopamine-beta-hydroxylase (DBH); monoamine oxidase type B (MAO-B); polymorphism

Subjects:

BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences

Divisions:

Division of Molecular Biology
Division of Molecular Medicine

Projects:

Project title	Project leader	Project code	Project type
Serotonergic neurotransmission: genes, proteins and behavior (Serotonergična neurotransmisija: geni, proteini i ponašanje)-	Jasminka Štefulj	098-1081870-2395	MZOS
Neurobiological basis of autism: The role of serotonin system (Neurobiološka podloga autizma: uloga serotoninskog sustava)-	Dubravka Hranilović	119-1081870-2396	MZOS
Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)-	Dorotea Muck-Šeler	098-0982522-2457	MZOS
Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)-	Nela Pivac	098-0982522-2455	MZOS