Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults

Nikolac Perković, Matea; Mustapić, Maja; Pavlović, Mladen; Uzun, Suzana; Kozumplik, Oliver; Barišić, Ivan; Muck-Šeler, Dorotea; Pivac, Nela (2013) Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults. Neuroscience letters, 545 . pp. 127-131. ISSN 0304-3940

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Abstract

Obesity is becoming the epidemic health problem worldwide with a very complex etiology. The interaction between diverse genetic and environmental factors contributes to development of obesity. Among myriad of functions in central and peripheral tissues, brain-derived neurotrophic factor (BDNF) also regulates energy homeostasis, food intake and feeding behavior, and has a role in obesity and increased body mass index (BMI). BDNF Val66Met (rs6265) polymorphism is associated with BMI gain, but both positive associations and non-replications are reported. Since BMI changes over time and since genetic influences on BMI vary with age, the aim of the study was to evaluate association between BDNF Val66Met polymorphism and BMI gain in healthy subjects with middle or old age. The study included a cohort of 339 adult healthy Caucasians of Croatian origin, free of eating and metabolic disorders, evaluated in three time periods in the year 1972, 1982 and 2006, when the subjects were around 40, 50 and 70 years old, respectively. The results revealed a significant effect of smoking on BMI, but a lack of significant association between BDNF Val66Met polymorphism and overweight or obesity, and no significant association between BDNF Val66Met and BMI changes over time. These results did not confirm the major role of BDNF Val66Met in the regulation of BMI changes in adult and old healthy subjects.

Item Type:	Article
Uncontrolled Keywords:	Brain-derived neurotrophic factor; Val66Met polymorphism; Body mass index; Healthy subjects; Weight change over time
Subjects:	BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Side effects of psychopharmacs in patients with psychosis and mood disorders (Nuspojave psihofarmaka u bolesnika s psihotičnim i afektivnim poremećajima)- Suzana Uzun 108-1083509-3511 MZOS Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)- Dorotea Muck-Šeler 098-0982522-2457 MZOS Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)- Nela Pivac 098-0982522-2455 MZOS
Depositing User:	Matea Nikolac Perković
Date Deposited:	02 Dec 2015 14:05
URI:	http://fulir.irb.hr/id/eprint/2358
DOI:	10.1016/j.neulet.2013.04.036

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