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Robust demarcation of basal cell carcinoma by dependent component analysis-based segmentation of multi-spectral fluorescence image

Kopriva, Ivica; Peršin, Antun; Puizina-Ivić, Neira; Mirić, Lina (2010) Robust demarcation of basal cell carcinoma by dependent component analysis-based segmentation of multi-spectral fluorescence image. Journal of Photochemistry and Photobiology B: Biology, 100 (1). pp. 10-18. ISSN 1011-1344

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Abstract

This study was designed to demonstrate robust performance of the novel dependent component analysis (DCA)-based approach to demarcation of the basal cell carcinoma (BCC) through unsupervised decomposition of the red–green–blue (RGB) fluorescent image of the BCC. Robustness to intensity fluctuation is due to the scale invariance property of DCA algorithms, which exploit spectral and spatial diversities between the BCC and the surrounding tissue. Used filtering-based DCA approach represents an extension of the independent component analysis (ICA) and is necessary in order to account for statistical dependence that is induced by spectral similarity between the BCC and surrounding tissue. This generates weak edges what represents a challenge for other segmentation methods as well. By comparative performance analysis with state-of-the-art image segmentation methods such as active contours (level set), K-means clustering, non-negative matrix factorization, ICA and ratio imaging we experimentally demonstrate good performance of DCA-based BCC demarcation in two demanding scenarios where intensity of the fluorescent image has been varied almost two orders of magnitude.

Item Type: Article
Uncontrolled Keywords: basal cell carcinoma; photodynamic detection; dependent component analysis; tumor demarcation; multi-spectral image
Subjects: TECHNICAL SCIENCES > Computing > Data Processing
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Laser and Atomic Research and Development
Projects:
Project titleProject leaderProject codeProject type
Multispectral data analysis (Analiza višespektralih podataka)-Ivica Kopriva098-0982903-2558MZOS
PHOTODYNAMIC THERAPY IN DERMATOLOGIC ONCOLOGY (FOTODINAMSKA TERAPIJA U DERMATOLOŠKOJ ONKOLOGIJI)Neira Puizina Ivić141-2180056-0481MZOS
Depositing User: Ivica Kopriva
Date Deposited: 24 Nov 2015 15:34
Last Modified: 24 Nov 2015 15:34
URI: http://fulir.irb.hr/id/eprint/2330
DOI: 10.1016/j.jphotobiol.2010.03.013

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