Geographical distribution and clinical relevance of non-tuberculous mycobacteria in Croatia

Janković, Mateja; Samaržija, Miroslav; Sabol, Ivan; Jakopović, Marko; Katalinić-Janković, Vera; Žmak, Ljiljana; Tićac, Brigita; Marušić, Ante; Obrovac, Mihaela; van Ingen, Jakko (2013) Geographical distribution and clinical relevance of non-tuberculous mycobacteria in Croatia. International Journal of Tuberculosis and Lung Disease, 17 (6). pp. 836-841. ISSN 1027-3719

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Abstract

The clinical relevance of non-tuberculous mycobacteria (NTM) in Croatia is unknown. Objective is to estimate the isolation rate of NTM, record geographical differences and assess the burden of pulmonary NTM disease in Croatia. Design was Nationwide retrospective cohort study of all Croatian residents with NTM isolated by culture in the period from 2006 to 2010. Microbiological criteria of the American Thoracic Society were used to establish a laboratory-based case definition of possible and probable NTM disease. Of 1187 individuals with pulmonary NTM isolates, 8.6% met the possible and 5.5% met the probable disease criteria. We estimated an annual incidence of probable pulmonary NTM disease of 0.23 per 100 000 population. This estimated annual incidence was 0.35/100 000 in the coastal region and 0.17/100 000 in the continental region. Species distribution differed between coastal and continental Croatia. NTM isolation frequency increased over the study period. Geography plays an important role in NTM species distribution and possible disease. The overall burden of NTM pulmonary disease in Croatia is still low compared to that of tuberculosis, but it is higher in the coastal region compared to the continental region.

Item Type:	Article
Uncontrolled Keywords:	atypical mycobacteria; epidemiological study; geographical diversity; pulmonary NTM disease
Subjects:	BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Ecological aspects of Legionelloses (Ekološki aspekti legioneloza)- Brigita Tićac 062-0621273-0952 MZOS Aberrant DNA methylation in HPV associated lesions (Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima)- Magdalena Grce 098-0982464-2510 MZOS
Depositing User:	Ivan Sabol
Date Deposited:	13 Nov 2015 17:06
URI:	http://fulir.irb.hr/id/eprint/2248
DOI:	10.5588/ijtld.12.0843

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