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Mechanochemical Ritter reaction: a rapid approach to functionalized amides at room temperature

Dokli, Irena; Gredičak, Matija (2015) Mechanochemical Ritter reaction: a rapid approach to functionalized amides at room temperature. European Journal of Organic Chemistry, 2015 (12). pp. 2727-2732. ISSN 1434-193X

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A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment, utilizing a Brønsted acid catalyst. Its general application has been verified through a substrate screening investigation comprising a wide range of functionalized nitriles, as well as secondary and tertiary alcohols.

Item Type: Article
Additional Information: This is the accepted version of the following article: Mechanochemical Ritter Reaction: A Rapid Approach to Functionalized Amides at Room Temperature / Irena Dokli andMatija Gredičak, European journal of organic chemistry, 2015, 12; 2727-2732. which has been published in final form at
Uncontrolled Keywords: mechanochemistry; organocatalysis; Ritter reaction; amides
Subjects: NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Project titleProject leaderProject codeProject type
Chemical transformations of natural compounds (Kemijske preobrazbe prirodnih spojeva)-Lidija Varga-Defterdarović098-0982933-2936MZOS
Chiral building blocks for biological active molecules. Synthesis and reactivity (Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost)-Zdenko Hameršak098-0982933-2908MZOS
Depositing User: Matija Gredičak
Date Deposited: 28 Oct 2015 15:16
DOI: 10.1002/ejoc.201500051

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