Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients

Grbeša, Ivana; Pajares, María J.; Martínez-Terroba, Elena; Agorreta, Jackeline; Mikecin, Ana-Matea; Larráyoz, Marta; Idoate, Miguel A.; Gall-Troselj, Koraljka; Pio, Ruben; Montuenga, Luis M. (2015) Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients. PLoS ONE, 10 (4). e0124670/1-e0124670/17. ISSN 1932-6203

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Abstract

Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases in lung cancer biology.

Item Type:	Article
Uncontrolled Keywords:	bronchial epithelial-cells; dependent pathway; prostate-cancer; regulates sirt1; breast-cancer; growth; p53; deacetylase; senescence; carcinoma
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Ana-Matea Mikecin
Date Deposited:	09 Jul 2015 12:21
URI:	http://fulir.irb.hr/id/eprint/2052
DOI:	10.1371/journal.pone.0124670

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