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Mannose 6-phosphate/insulin-like growth factor 2 receptor in carcinogenesis

Martin-Kleiner, Irena; Gall Trošelj, Koraljka (2010) Mannose 6-phosphate/insulin-like growth factor 2 receptor in carcinogenesis. Cancer letters, 289 (1). pp. 11-22. ISSN 0304-3835

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The cation independent mannose 6-phosphate/insulin-like growth factor 2 (M6P/IGF2R) is a multifunctional receptor. It is included in a variety of cellular processes which become disregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.

Item Type: Article
Uncontrolled Keywords: mannose 6-phosphate/insulin-like growth factor 2 receptor; LOH; mutation; cancer
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata-Koraljka Gall-Trošelj098-0982464-2511MZOS
Depositing User: Irena Martin Kleiner
Date Deposited: 22 Dec 2016 16:42
DOI: 10.1016/j.canlet.2009.06.036

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