Radić Stojković, Marijana; Škugor, Marko; Tomić, Sanja; Grabar, Marina; Smrečki, Vilko; Dudek, Lukasz; Grolik, Jaroslaw; Eilmes, Julita; Piantanida, Ivo (2013) Dibenzotetraaza[14]annulene – adenine conjugate recognizes complementary poly dT among ss-DNA / ss-RNA sequences. Organic and Biomolecular Chemistry, 11 (24). pp. 4077-4085. ISSN 1477-0520
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Abstract
Among three novel DBTAA derivatives only the DBTAA-propyl-adenine conjugate 1 showed recognition of the consecutive oligo dT sequence by increased affinity and specific induced chirooptical response in comparison to other single stranded RNA and DNA; whereby of particular importance is the up until now unique efficient differentiation between dT and rU. At variance, its close analogue DBTAA-hexyl-adenine 2 did not reveal any selectivity between ss-DNA/RNA pointing out the important role of steric factors (linker length); moreover non-selectivity of the reference compound (3, lacking adenine) stressed the importance of adenine interactions in the 1 selectivity.
| Item Type: | Article | ||||||||||||||||||||||||
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| Additional Information: | Financial support by the Ministry of Science, Education, Sport of Croatia (098-0982914-2918, 098-1191344-2860), the Grant (WCh-BW) Jagiellonian University, Krakow, Poland, European Regional Development Fund, Polish Innovation Economy Operational Program (contract POIG.02.01.00-12-023/08) is acknowledged. | ||||||||||||||||||||||||
| Uncontrolled Keywords: | circular-dichroism; aqueous-media; complexes; binding; polynucleotides; equilibrium; derivatives; affinity; adenine; sites | ||||||||||||||||||||||||
| Subjects: | NATURAL SCIENCES > Physics NATURAL SCIENCES > Chemistry |
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| Divisions: | Division of Organic Chemistry and Biochemistry NMR Center |
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| Depositing User: | Vilko Smrečki | ||||||||||||||||||||||||
| Date Deposited: | 10 Jan 2017 09:28 | ||||||||||||||||||||||||
| URI: | http://fulir.irb.hr/id/eprint/1246 | ||||||||||||||||||||||||
| DOI: | 10.1039/C3OB40519B |
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