Rho GTPases in Model Systems

Filić, Vedrana; Weber, Igor (2023) Rho GTPases in Model Systems. Cells, 12 (5). ISSN 2073-4409

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Abstract

Since the discovery of their role in the regulation of actin cytoskeleton 30 years ago, Rho GTPases have taken center stage in cell motility research. Over time, it has become clear that these “molecular switches” are also involved in the regulation of other cellular processes, such as cell polarization, cell differentiation and growth, membrane trafficking, and transcriptional regulation. The biological importance of Rho GTPases is exemplified by the fact that mammalian cells invest more than 150 genes that encode their direct regulators. Rho GTPases are essential signaling molecules in mammals and across the whole eukaryotic domain. This Special Issue of Cells represents a collection of review articles and original research papers covering Rho GTPases in model organisms and cell culture systems. It can be roughly divided into sections devoted to evolutionary aspects, screening and mechanistic approaches, and the roles of Rho GTPases in mammalian physiology and pathology.

Item Type:	Article
Uncontrolled Keywords:	Rho GTPases
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Division of Molecular Biology
Depositing User:	Josipa Karadžole
Date Deposited:	13 Apr 2026 13:41
URI:	http://fulir.irb.hr/id/eprint/11679
DOI:	10.3390/cells12050779

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