Editorial: Integrin adhesion receptors in health and disease

Kostourou, Vassiliki; Goult, Benjamin T.; Ambriović-Ristov, Andreja (2023) Editorial: Integrin adhesion receptors in health and disease. Frontiers in Cell and Developmental Biology, 11 . ISSN 2296-634X

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Abstract

Cells sense the chemical and mechanical properties of their environment. In animals, one mechanism for this sensing is via the direct attachment of cells to the surrounding extracellular matrix (ECM). Mediated by the integrin protein family of ECM receptors, integrin adhesion complexes (IACs) engage various ligands of the ECM as well as counter receptors on neighbouring cells. An emerging property of IACs that is essential for tissue homeostasis is their role in cell mechanotransduction, a process whereby cells are able to sense and respond to mechanical cues and convert them into biological signals to elicit different cellular responses. By coupling extracellular ligands to the actin cytoskeleton, microtubules and intermediate filaments, these IACs constitute sites of signalling integration that regulate central cellular functions. The dense, highly dynamic protein assemblies associated with IACs are collectively referred to as the integrin “adhesome” and its mis-regulation is central to a wide variety of developmental and pathological processes. In this Research Topic the full breadth of integrin adhesion biology was explored in a series of 15 articles.

Item Type:	Article
Uncontrolled Keywords:	adhesion; integrin; extracellular matrix; integrin adhesion complex; integrin signalling
Subjects:	NATURAL SCIENCES > Biology NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions:	Division of Molecular Biology
Depositing User:	Josipa Karadžole
Date Deposited:	13 Apr 2026 12:16
URI:	http://fulir.irb.hr/id/eprint/11669
DOI:	10.3389/fcell.2023.1149920

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