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First hydroxamic seconucleoside derivatives

Vrček, Valerije; Čaplar, Vesna; Uršić, Stanko (1998) First hydroxamic seconucleoside derivatives. Croatica Chemica Acta, 71 (1). pp. 119-124. ISSN 0011-1643

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Nucleoside analogues possessing hydroxamate moiety were prepared from secouridine derivatives oxidized at C(2')-position. 3',5'-O-Isopropylidene-2',3'-secouridine was oxidized with CrO3/py complex to the carboxylate level and with DMSO/DCC to the aldehyde level. Both compounds (precursors) gave C(2')-nucleoside hydroxamic acids in the reaction with hydroxylamine or nitrosobenzene in the presence of Fe3+ ions, respectively.

Item Type: Article
Uncontrolled Keywords: coli ribonucleotide reductase; escherichia-coli; virus type-1; inhibition; hydroxyurea; cells; acids; replication; subunit; analogs
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Project titleProject leaderProject codeProject type
Interakcije nitrozospojeva s biomedicinski važnim molekulamaStanko Uršić006142MZOS
Mehanizam reakcije stvaranja steroidnih spojevaOlga Kronja006151MZOS
Projektiranje i sinteza supramolekularnih sustavaMladen Žinić00980703MZOS
Depositing User: Vesna Čaplar
Date Deposited: 28 Nov 2013 11:38

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