hrvatski jezikClear Cookie - decide language by browser settings

Protective effects of Met-enkephalin on alcohol induced gastric lesions

Konjevoda, Paško; Štambuk, Nikola; Vikić-Topić, Dražen; Boban-Blagaić, Alenka; Vikić-Topić, Smiljka; Mrljak, Vladimir; Ramadan, Pero; Biđin, Zdenko (2000) Protective effects of Met-enkephalin on alcohol induced gastric lesions. Croatica Chemica Acta, 73 (4). pp. 1111-1121. ISSN 0011-1643

[img] PDF - Published Version
Download (91kB)

Abstract

The model of ethanol induced gastric lesions is useful in the evaluation of gastric cytoprotection. We used it to measure cytoprotective effects of two neuropeptides, Met-enkephalin (Peptid-M, LUPEX(R)) and alpha -melanocyte stimulating hormone (alpha -MSH). Both peptides exhibited significant and synergistic cytoprotective effects. The best therapeutic efficacy was obtained with Met-enkephalin and alpha -MSH mixture 3-5:1. Significant cytoprotective action on ethanol induced lesions was also observed by means of two thymus peptide immunomodulators, Thymus Peptide C(R) and JAN 50(R). Thymus Peptide C(R) exhibited a more significant synergistic effect with Met-enkephalin than JAN 50(R). In addition to the cytoprotection of rat gastric mucosa, Met-enkephalin also induced statistically significant and dose dependent Straub tail response versus control in mice. Haloperidol, naloxone and Peptide-D antagonised its effects. NMR spectrospic data supported molecular interaction of Metenkephalin and haloperidol, while neutralization of Met-enkephalin induced Straub tail response by means of Peptide-D indicated the presence of new non-opioid (naloxone independent) receptor system containing Peptide-D sequence (calpastatin 201-205 aa).

Item Type: Article
Uncontrolled Keywords: Met-enkephalin; LUPEX (R); alpha-MSH; ethanol; gastric lesions; peptide-D; cytoprotection; Straub phenomenon; haloperidol; NMR; Thymus Peptide C (R); JAN 50 (R); mucosal injury; alpha-msh; peptid-m; cyclooxygenase-2; neutrophils; rat
Subjects: NATURAL SCIENCES > Chemistry
Divisions: NMR Center
Projects:
Project titleProject leaderProject codeProject type
Izotopno obilježavanje i molekulske spektroskopijeGoran Baranović00980802MZOS
Cijepljenje virusnim podjedinicamaBiserka Pokrić00981108MZOS
Epizootiologija i suzbijanje zarazne bolesti burzeZdenko Biđin053006MZOS
Depositing User: Nikola Štambuk
Date Deposited: 21 Nov 2013 12:56
Last Modified: 27 Feb 2014 14:32
URI: http://fulir.irb.hr/id/eprint/1030

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year